Immunological studies on the locally prepared Bivalent vaccine of ‎spirochaeta and newcaste disease

Abstract: Spirocheata and NewCastle disease are the most important respiratory and ‎disease affecting poultry and cause a great economic losses due to highly ‎rate of morbidity and mortality as well as drop in egg production so the aim ‎of this study is to produce a locally combined vaccine / ND v and ‎spirochaeta against both disease for a aving tie , effort and money the ‎evaluation of the all vaccines (combined / NDV vaccine / spirochaeta) for ‎the priority and safety , and all vaccine were free from any bacterial , virus , ‎fungal contaminants the serologicaly examination to sera sample collected ‎from chickens vaccinated by the combinedvaccine (NDV and spirochaeta) , ‎lyophilized spirochaeta vaccine and formalized inactivated N.D.V was done ‎by selected serological test H1 test , SNT test slid agglutination test and ‎ELISA test. Also came be evaluation the cellular immune response by ‎lymyhocte trans formation test by using the mitogen. One for B. Cell and the ‎other for T. Cell. All this test used for the evaluation of the immune ‎response and immunity which a quired to bird from vaccinated with all ‎vaccinated mention befor. All result of locally prepared combined vaccine ‎give highly and stable immune response than the NDV vaccine and ‎spirochaeta vaccine especially in the last part of the experiment. Due to the ‎wide spread of spirochaeta among fowls in Egypt . locally prepared ‎combined vaccine can be used safely in vaccination against both disease ‎‎(spirochaeta and NDV). Early vaccination against both disease are urgent ‎demand in poultry industry as the present study proved that the combined ‎vaccine can be inoculated safely at end of the first week in chicks ‎
Publication year 2003
Availability location مكتبة معهد بحوث الامصال واللقاحات البيطرية.
Availability number
Organization Name
Country Egypt
Publisher Name: جامعة الزقازيق
External authors (outside ARC)
    على محمد سليمان الجد كلية طب بيطرى مشتهر
    عادل محمود عبد المجيد خالد كلية طب بيطرى مشتهر
    زين العابدين عبده محمد كلية طب بيطرى مشتهر
Proposed Agrovoc Bivalent vaccine;Locally prepared;Poultry diseases;Poultry vaccines;chickens diseases;
Publication Type PhD Thesis
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