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The effect of pefloxacin on pseudomonas aeruginosa experimental infection in quails.
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Abstract: A total number of three handred samples of Quail of different ages were collected from apparently healthy and clinically diseased farms in North Sinai Governorate. The diseased birds were suffering from respiratory disorders, profuse diarrhea, and high mortality rate, especially in young birds.Perihepatitis and pericarditis. Samples were taken for bacteriological examination from the intestine, spleen, lung, liver and kidney. Sixity isolates (20%) Pseudomonas aeruginosa were recorded from the bird samples. Sensitivity test for the isolates revealed that Pefloxacin and ciprofloxacin were highly effective. Experimental infection of 180 quails, one day of age divided into 9 equal groups of 20 each was curried out intranasally with 0.2 ml of a suspension containing 3x 108 CFU/ml of Pseudomonas aeruginosa isolate. Three groups were infected and treated with different doses (5,10 and 20 mg/ kg body weight) of Pefloxacin in drinking water for 5 successive days before infection and other3 similar groups 24 hours after infection. Two groups served as control and infection control. At the end of the experiment (3 weeks) samples for bacteriological, biochemical and histopathological examinationwere collected.Pefloxacin was reducing mortality rate, decrease the severity of gross pathological lesions and improve the body weight gain. Moreover, the control non infected and treated group with Pefloxacin at level of (10mg/kg b.w.) exhibited the highest weight gain. Pefloxacin at dose levelof (10 or 20 mg/ kg b.w.) was highly effective in controlling,Pseudomonase aeruginosa infection specially when used 24 hours before infection, while lower doses had little effect. The infected no treated group showed highly significant increase in serum for kidney and liver function enzymes and severe histopathological changes in defferent organs. Moderate and mild alteration were seen intreated birds with pefloxacin especially at prophylactic doses.
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| Publication year |
2003
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| Availability location |
Animal Health Research Institute (AHRI) --Nadi El-Said Street - Dokki - Giza
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| Availability number |
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| Organization Name |
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Pseudomonas aeruginosa.
Quails.
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| Proposed Agrovoc |
Pefloxacin;
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| Publication Type |
Journal
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