Some biochemical hormonal, haematological and histoipathological changes following multiple dose therapy of closantel in female rabbit

Abstract: The effects of multiple closantel administration on some hematological, serum biochemical, reproductive hormones and it is histopathological findings were studies on 2 groups of 10 female mature rabbits each. The first group was used as control and the second group was subcutanously injected daily, with closantel on a dose of 10 mg/kg body weight for 15th days. The treatment resulted in significant (p<0.05) decrase in red blood cells corpuscles, white blood cells corpuscles, hemoglobin concentrations and packed cell volume. Also closantel significantly (p<0.05) decreased total protein, albumin, a and b globulin concentrations while it significantly increased o globulin concentration (p<0.05)Concerning reproductive hormones, closantel significantly decreased serum progesterone and estrogen concentrations compared with the control group (p<0.05). Histopathological studies revealed degenerative changes in liver and kidney tissues, spleen and lung tissues were congested with hemorrhagic areas and the ovarian tissues showed decreases in the number of follicles (activated, growing and antral follicles) in closantel treated group compared with the control group. Collectively, these studies indicate that multiple doses of closantel have cytotoxic effects on parenchymatus organs and detrimental effects upon reproduction. So it is advisable to avoid exposure of female animals to multiple doses of this anthelmintic drug.
Publication year 2002
Availability location مكتبة معهد بحوث التناسليات الحيوانية
Availability number
Organization Name
Author(s) from ARC
Agris Categories Animal physiology - Reproduction
Proposed Agrovoc female rabbit;
Publication Type Researsh & Applied Activities
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