A Survey of Newly Born Buffalo Calves with Acute Diarrhea or Pneumonia: Bacterial Causes and Comparison of two Drug Therapies
Abstract: ABSTRACT:
This study investigated the therapeutic efficacy of ciprofloxacin (CPLX) Trimethoprim-sulphamethoxazole (TMPSMX) on buffalo calves (1-60 days old) suffering from acute diarrhoea or pneumonia. Additionally, possible bacterial pathogens were isolated and identified before and after as well as during the treatment course which was prolonged for continous five days with each drug. Both drugs were given orally with CPLX daily dose of I g/calf divided into two doses while TMPSMX dose was one tablet(160mgTMP+800mgSMX)/calf every/2hrs. Bacteriological investigation revealed that E. coli was the most widespread diarrhoea-associated bacteria besides other members of entemhacteriaceae. Among pneumonic cases, gram-positive cocci were identified in addition to E. coli and other gram-negative bacilli. The efficacy of each drug therapy was evaluated according to both clinical and bacteriological findings. Ciprojloxacin was found superior to TMPSMX in treatment of diarrea with clinical recovery rates of 100% and 50% respectively. In pneumonic calves, recovery rate was also slightly higher (90%) with CPXL than with TMPSMX (80%). Moreover, a quicker recovery (2-3 days) was noticed with CPLX while TMPSM X needed at least five days to show clinical results. while no losses were recorded with CPLX therapy, three claves died due to severe dehydration when , Tmpsmx was given to the diarrhoeic calves. Cummulative effects and clearance rates were investigated by detecting the levels of both drugs in serum samples taken from the treated calves. Our results indicated that ciprofloxacin can be used to minimize the losses among newly born buffalo calves due to bacterial dependent respiratory and intestinal disorders
Publication year 2000
Pages 16-18
Availability location معهد بحوث التناسليات الحيوانية بالهرم
Availability number
Organization Name
Author(s) from ARC
External authors (outside ARC)
    محمود حشاد كلية الطب البيطرى-جامعة القاهرة
Agris Categories Veterinary science and hygiene - General aspects
Publication Type Researsh & Applied Activities
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