Effect of Meglumine antimonite (ant leishmaniasis drug) on newborn calves immunity.
Abstract:
The significant immuno-modulating effect of Meglumine antimonite (anti-leishmaniasis drug), MA, on Frisian newborn calves was estimated when it was administrated simultaneously with score guard vaccination to their dams at late pregnancy. MA potentiated the K99 and Rotavirus antibodies titers in sera of treated and vaccinated dams, (they raised to levels of 3900 ± 92 & 1200 ± 81, respectively) and in their colostrum as they increased to higher levels (20480 ±3125 & 5632 ±1254, respectively) in comparing with that of vaccinated only cows group or control group (neither vaccinated nor MA treated). Calves born to dams vaccinated &treated with MA either 1 or 2 doses exhibited maximum K99 and Rotavirus antibody titers in their blood at the ages of 1–3 weeks. The antibody titers were running parallel to the results of the total protein and ZST; IgG and IgM in sera of treated dams, their colostrum and their calves’ sera for up to 2 months of age. MA supplementation at the time of vaccination in pregnant dams augmented the IgG and IgM values in cows’ sera as well as in colostrum to the levels higher than that in other groups that reflected to the significant increase in IgG and IgM level in calves’ sera that born to MA treated dams. Moreover, MA was resulted in slight elevation in colostral specific gravity (SG) and consequently the total immunoglobulins contents as the SG is an indirect evaluation for the immunoglobulins. In conclusion, application of immuno-stimulant as MA increased the specific and non-specific immune response in dams sera and colostrum as well as calves sera, in addition to improvement the body weight gain in calves besides, the clinical observation e.g. morbidity and mortality rates
Publication year 2011
Pages 227-244.
Organization Name
Country Egypt
serial title المؤتمر العربى التاسع والعشرون للطب البيطرى
Author(s) from ARC
Publication Type Journal
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