Studies on cell mediated immune response of goats vaccinated with goat pox vaccine
Abstract: Vaccination of goats with tissue culture goat pox vaccine is considered the main route of protection against goat pox disease. In this study, the cell mediated immune response was detected in goats vaccinated and challenged with goat pox vaccine and virulent goat pox virus respectively. It was estimated by using the lymphocyte transformation test. The results revealed that the lymphocytes increased from the 3rd day post vaccination in cells with mitogen phytohaemagglutinin (PHA) (0.382) and reached its peak on the 10th day post vaccination (0.451) and decreased (0.294) till the challenge time (30th day post vaccination). On the other hand, lymphocytes returned to increase again after challenge where their levels reached the maximum on the 10th day post challenge (0.64) and then a remarkable decline occurred till the 30th day post challenge (0.322). the results of cell mediated immune response was compared and confirmed with that of the humoral immune response, where the serum neutralization test (SNT) and enzyme linked immunosorbent assay (ELISA) revealed that the neutralizing antibodies appeared clearly at the 14th day post vaccination (decline time of the cellular immune response) and reached its peak at the 21st day and then declined but persisted within the protective levels. As well, the antibody levels recorded another increase post challenge, this increase was higher than that recorded post vaccination.
Publication year 2002
Pages 139-151
Availability location مكتبة كلية الطب البيطري بجامعة الزقازيق
Availability number
Organization Name
City الزقازيق
serial title المؤتمر العلمي السادس لكلية الطب البيطري بجامعة الزقازيق
Author(s) from ARC
Agris Categories Animal diseases
Proposed Agrovoc Goats--Diseases;Goats--Diseases--Preventive;
Publication Type Conference/Workshop
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