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Studies on factors influencing the immune response of tissue culture Rinderpest vaccine under Laboratory and field conditions
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Abstract: The aim of this work is to study the effect of some factors on the immune response to tissue culture rinderpest vaccine under various laboratory and field conditions.
Experiment (1) studied the effect of storage at various degrees of temprature for different periods of time on the virus titre of tcRP vaccine. It was found that vaccine ampoules stored at-20oC TO -70oC for 7 months gave the best results while vaccine vials stored at -20oC FOR 5 MONTHS AND AT -70Oc FOR 3 months showed stable virus titre.
The aim of experiment (2) was to study the effect of transportation and storage of TcRP vaccine vials at dofferent Governorates on the virus titre. The obtained results showed clear significant decrease in the vieus titre after transportation and storage at Kaliobia, Damitta and Assiut Governorates, probably due to enviromental factors.
The effect of vaccination dose on the immune response of calves vaccinated with TcRP vaccine was studies in experiment (3). The obtained data show that the immune response increases with increasing the dose up to a maximum above which the immunological tolerance occur.
Experiment (4) was planned to find out the effect of vaccination repetitions of TcRP vaccine on the immune response of susceptible calves. It is concluded from the obtained results that repetitions of vaccination with TcRP vaccine have no significant effect on the serum neutralizing antibody titres of the vaccinated calves.
The aim of experiment 5.6.7 and 8 was to study the effect of simultaneous vaccination with TcRP vaccine and one Haemorrhagic septicaemia or BCG vaccine on the immune response of susceptible calves to the first vaccine. It was proved clearly that such simultaneous vaccinations have no significant effect on the immune response of calves to Tcrpv vaccine.
As regards experiment (9); the effcet of blood parasites on the immune response of cattle vaccinated with TcRP vaccine; no clear significant difference in the rindrpest serum neutralizing antibodies could be observed between healthy and chronic infested animals.
The effect of seasonal variations on the immune response of calves vaccinated with TcRP vaccine was studies in experiment (10). The registered results prove that the antibody titres of calves vaccinated during summer were slightly lower than those vaccinated during autumn or winter.
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| Publication year |
1987
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| Availability location |
معهد بحوث الامصال واللقاحات البيطرية
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| Availability number |
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| Organization Name |
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| Country |
Egypt
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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| Proposed Agrovoc |
Rinderpest vaccine;
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| Publication Type |
PhD Thesis
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