Investigation of cellular and humoral immunity of rabies, canine distemper and canine parvo in vaccinated puppies
Abstract: Cellular and humoral immune response of puppies to locally produced canine distemper (CD) canine parvo (CP) and rabies vaccines in single and trivalent forms, were evaluated using lymphocyte blastogenesis assay (using MTT) and serum neutralization test (SNT). It was found that there were no antagonizing effects between the three vaccinal antigens on the humoral immune responses of vaccinated animals while the cellular ones were higher in the trivalent vaccination than in single vaccination. It was also noticed that CD induced the highest cellular immune response while CP induced the highest levels of humoral antibodies. Also the antigens value of rabies vaccine did not affect by the addition of CD and CP vaccines. The results of challenge test showed faster and higher levels of cellular immune response which persist ten days post challenge. On the other hand, there was decrease in the levels of neutralizing antibodies in vaccinated animals one week post challenge and reached to the peak titer by the third week
Publication year 2003
Pages 11
Organization Name
City بني سويف
serial title مجلة جامعة بني سويف الطبية البيطرية
Author(s) from ARC
External authors (outside ARC)
    سمير محمد ادريس
    اماني علي صالح معهد بحوث الأمصال واللقاحات البيطرية
Agris Categories Animal diseases
AGROVOC
TERMS		 Canine parvovirus. Distemper virus. Humoral immunity. Immune response. Lymphocytes. Rabies. Vaccination. Viroses.
Publication Type Journal
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