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Necrotic Enteritis in Chickens and trial for vaccine preparation from the Toxins of isolated Clostridium perfringens
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Abstract: In the present study 305 (72.6%) isolates of C.perfringens type A were isolated from liver and intestine of 420 dead broiler chickens with post mortem lesions of NE.In addition to 25 (31.25%)isolates of C.perfringens type A were isolated from liver and intestine of 80 dead broiler chickens with no gross lesions of necrotic enteritis (NE).Toxoid vaccine adjuvanted with 20% Aluminum hydroxide gel was prepared from the most toxigenic C.perfringens type A strains. Vaccination of two groups of 2 weeks old chicks with 0.25ml and 0.5ml of the prepared toxoid revealed a high antitoxin titer against C.perfringens type a (0.5 IU/ml and 0.9 IU/ml respectively). Also vaccination of two groups of chickens 6-8 weeks of age with 0.5ml and one ml of the prepared toxiod revealed a high titer (0.7IU/ml and 2IU/ml respectively). The inclusion of antibacterial feed additives has until now been the major strategy for controlling clostridium perfringens (C.perfringens) associated necrotic enteritis (NE) in broilers. These antibacterial feed addititves may have bad effect on the consumer as well as drug resistant they develop. So, Immunoprophylaxis seems to be an interesting alternative for the control of necrotic enteritis in chickens.
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| Publication year |
2007
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| Pages |
1
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| Organization Name |
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| City |
بنها
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| serial title |
مجلة بنها الطبية البيطرية
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| Author(s) from ARC |
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| External authors (outside ARC) |
ابراهيم محمد البرعي
قسم الدواجن-كلية الطب البيطري/جامعة بنها
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Chickens.
Clostridium perfringens.
Toxins.
Vaccination.
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| Publication Type |
Journal
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