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Detection of immune response against tetanus in pregnant mares and their foals injected with tetanus taxied.
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Abstract: This study was applied for tracing the immune response in pregnant mares, injected with tetanus toxoid, and determining the passive immunity in their foals. The pregnant mares were injected with tetanus toxoid plus DEAE- dextran adjuvant, 8 and 4 weeks before foaling. Both humoral and cellular immune responses were elevated and could protect them against tetanus. The humoral response declined gradually during the 36 weeks after the booster dose (3 IU); but the cellular immune response persisted (Optical Density 0.53). neither the antibodies nor the T-cells passed, the placenta to foals during the womb life. Foals, from the immune mares, gained passive protective immunity through colostrum and were still immune for 22 weeks after labour, as they showed (0.4 IU) which is safe and protective. At 26 week it declines to 0.06 IU which is not safe for the foal. For active immunization of these foals, tetanus toxoid should be injected at 22-26 weeks of age when the maternal immunity declines. The long term of material immunity in foals, from immune mares, ensures the use of DEAE-Dextran as an adjuvant and immunostimulant in the preparation of tetanus taxied vaccine.
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| Publication year |
2004
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| Pages |
26-33
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| Availability location |
معهد بحوث الامصال واللقاحات البيطرية.
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| Availability number |
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| Organization Name |
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| City |
الزقازيق
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| serial title |
Zag.Vet.J
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| ISSN |
1110-1458
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Foals.
Immune response.
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| Proposed Agrovoc |
against tetanus;tetanus toxoid;
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| Publication Type |
Journal
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