Preparation and evaluation of a combined vaccine against rabies and tetanus to be used in equines
Abstract: A combined vaccine was prepared against rabies abd tetanus using the inactivated cell culture rabies virus (ERA strain) and the tetanus toxoid and the Alhydragel was added as an adjuvant. Different groups of mice, rats and guinea pigs were vaccinated against rabies and tetanus singly and in a combined form where the passive haemagglutination, flocculation, serum neutralization and challenge tests showed that all of these vaccinated animals exhibited good levels of specific antibodies against rabies and tetanus and withstood the virulent strains of both with a protection rate of 90%.
Also there were no abnormal clinical signs noticed on the tested animals. Practical application of these experiments was carried out on different groups of local breed horses and donkeys using single and combined vaccines against rabies and tetanus. The ysed dose of the combined vaccine contained 25mg of rabies antigen and 100 LF of tetanus toxoid inoculated subcutaneously. The serological tests revealed that all vaccinated horses and donkeys exhibited high levels of rabies and tetanus antibodies without any antagonism between the immune response of them to rabies antigen or tetanus toxoid. Vaccinated horses and donkeys did not show any abnormal clinical signs. So, the rabies and tetanus combined vaccine is a safe and immunogenic vaccine and could protect equines against the two disease at the same time.
Publication year 2002
Pages 537-548
Availability location مكتبة معهد بحوث الامصال واللقاحات البيطرية.
Availability number
Organization Name
City Suez canal
serial title THE 2nd conference for Suez canal veterinary medecine journal
ISSN 1110-6298
Author(s) from ARC
External authors (outside ARC)
    وصفي ابراهيم جرجس
Agris Categories Animal diseases
AGROVOC
TERMS		 Rabies. Tetanus.
Proposed Agrovoc equines;
Publication Type Conference/Workshop
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