Prospects for livestock immunization to rinderpeste and lumpyskin disease using combined vaccines.
Abstract: Two bivalent vaccine pilot batches were prepard on cell cultures. The first one contained two vaccinal strains for rinderpeste and sheeppox viruses, while the other one was comprised of rinderpeste and lumpyskin disease virus vaccines. The titre of each virus used was 6.3, 6 and 5.2 Log10 TCID50/ml in tissue culture for rinderpeste, sheeppox and lumpyskin disease viruses respectively. The two viruses of each vaccine were pooled just before the processes of filling and lyophilization. The prepared vaccine were kept at -20° C till used. Four groups of cattle, naïve to both rinderpest and capripox viruses were used to verify the vaccines. The third group of cattle was subdivided into three subgroups each devoted for sole vaccination. The fourth subgroup was kept as nonvaccinated controls. The first group being inoculated with the 1st vaccine (RP/SP) exhibited neutralizing antibody (NA) titres of 100 and 128 for both viruses respectively. Whereas the second group gave NA titres of 50 and 256 for rinderpeste and lumpyskin disease viruses respectively. These titres remained as such from the 5th week till the third month post vaccination, when a recognizable decline in the NA titres especially for sheeppox and lumpyskin disease viruses occurred. It could be concluded that a satisfactory umbrella of protection was conferred to the animals immunized either with RP/SP or RP/LSD combined vaccines. This emphasizes on that there was neither antagonetic nor interference actions occureed between rinderpeste and capripox viruses as the acquired titres were simulating those usually coming out when these vaccines were utilized solely. The two vaccines proved to be absolutely safe for local breed cattle as no hyperthermia or clinical alterations were recorded. This paradigm could pave the way for further speculations aiming at economizing the waste in time, efforts and expenses that usually accompany the vaccination campaigns, as well as it could cut on the overexertion and the stresses on the human and animals levels.
Publication year 1999
Pages 1121-1128
Availability location معهد بحوث الامصال واللقاحات البيطرية
Availability number
Organization Name
City cairo
serial title 24th arab veterinary medical congress
Author(s) from ARC
Agris Categories Animal diseases
Proposed Agrovoc اللقاحات;
Publication Type Journal
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