Studies on potential activity of Amantadine on Rift valley Fever virus

Abstract: Evaluation of the antiviral activity of Amantadine Hydrochloride (AH) against Rift Valley Fever virus (RVFV) was performed in BHK cells (monolayer and cell suspension), babay, adult mice and sheep. AH had cytotoxic effect on BHK cells suspension, while it had 50% cytotoxicity on BHK monolayer at conc. of 3 mg/ml and no cytotoxic effect on baby mice till 5mg/ml. AH stop the replication of RVFV when inoculated at the same time and before inoculation of RVFV on BHK monolayer cells at concentration of 200ug/ml. Using AH before and at the same time with RVFV inoculation in adult mice cause high protection (100%), while using AH after 24, 48 and 72 hours of RVFV inoculation in adult mice leading to 90, 60 and 20% protection respectively. In sheep using the therapeutic dose of AH before and at the same time with RVFV infection showed no elevation of body temperature, while after 24 and 48 hrs it minimize the virus titer in sheep sera.
Publication year 2008
Pages 92-98
Availability location معهد بحوث الامصال واللقاحات البيطرية
Availability number
Organization Name
City Zagazig
serial title Zagazig veterinary medical journal
ISSN 1110-1458
Author(s) from ARC
Agris Categories Animal diseases
AGROVOC
TERMS		 Rift valley fever virus.
Publication Type Journal
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