Studies on the cumulative effect of sodium thiomersal on broilers Vaccinated with inactivated poultry vaccines

Abstract: Merthiolate (Thiomersal) is know to be used as antimicrobial agent in inactiveated vaccines without affecting vaccine potency. The present work investigated the effect of thiomersal contents in ND, AI and IBD inactivated vaccines on liver and kidney functions of vaccinated birds. The histopathological effect and the withdrawal time of such mercurial product from vaccinated chicken muscles were also investigated. Results revealed that residual thiomersal contents in ND, AI and IBD were 0.03 ; 0.02 and 0.03 mg/ml respectively. Liver and kidney function parameters showed significant increases in serum activities of alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) up to the 4th week post vaccination. Serum urea was significantly decreased on the 3rd week in vaccinated birds compared to control ones. Significant increase in serum creatinine in vaccinated chickens was recorded on the 5th weeks post vaccination. Liver and kidney functions parameters remain high allover the experimental period (8 weeks). The histopathological examination of liver spectimens revealed degeneration of hepatic cells and congestion of the central vein with inflammatory cell infiltration and congestion of blood vessels as well as coagulative necrosis. The spleen of vaccinated chickens showed depletion of lympocytes while lungs showed thickening of the alveolar. Mercury contents in muscle were 0.72, 0.52, 0.046 and 0.00 mg/kg on the 1st ,2nd , 3rd and 4th week post last vaccination that considered safe to the consumer. It is recommended that vaccinated poultry with inactivated vaccines containing thiomersal shouls not be slaughtered before at least 4 weeks and it is preferable to use combined inactivated vaccines to reduce the thiomersal contents as possible.
Publication year 2009
Organization Name
City Beni-Suef
serial title Beni-Suef Veterinary Medical Journal
ISSN 1687-7926
Author(s) from ARC
External authors (outside ARC)
    زينب سرور المعمل المركزي للرقابة على المستحضرات الحيوية
    انهار عبد المعطي المعمل المركزي للرقابة على المستحضرات الحيوية
    حنان محمد ابراهيم المعمل المركزي للرقابة على المستحضرات الحيوية
    محمد سيد
Agris Categories Animal diseases
Proposed Agrovoc ثيومرسال الصوديوم;دجاج التسمين;
Publication Type Journal
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