Fennel, carob, rosemary extracts as anti¬-inflammatory activity functions on formalin induced paw edema in albino rats
Abstract: Inflammation and oxidative stress are features of many degenerative illnesses. In this study, the anti-inflammatory and antioxidant effects of fennel (Foeniculum vulgare), carob (Ceratonia siliqua L), and rosemary (Rosmarinus officinalis L) extracts were investigated in vivo. Two models of formalin-induced paw edema were used to investigate the anti-inflammatory impact. The rat was given a formalin injection to cause an inflammatory process resulting in edema in the right leg. Formalin at 2.5% and 10% concentrations resulted in rat paw edema. In the anti-inflammatory study, Group 1: Normal control; no induced inflammation. Positive control (group 2) was given formalin. Rats were administered 200 and 400 mg/Kg b.w. of fennel extract to group 3, and group 4. Rats given formalin received carb extracts at dosages of 400 and 800 mg/kg. in Groups 5, and 6. Groups 7, 8: Formalin-treated rats were given 200 mg/kg b.w. and 400 mg/kg. of rosemary extracts. Group 9 includes rats administered formalin plus indomethacin at a dose of 10 mg/kg. In the two experimental formalin models (A and B), aqueous extracts and the standard drug were administered orally through a gastric tube 30 minutes after the formalin injection in the right hind of the rat paw. Following the 15-day trial period, blood and tissue samples were taken and histopathological and biochemical parameter analyses were done. In both models, all extract doses significantly reduced inflammation. In both models, each extract significantly reduced inflammation. According to research, these plants aqueous extracts effectively reduce inflammation in rat paw edema caused by formalin.
Key words:- Anti-inflammatory - Antioxidant Activities- carob- fennel – rosemary
Introduction
Publication year 2024
Pages 14-32
Organization Name
serial title Food Technology Research Journal.
Author(s) from ARC
Publication Type Journal
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