Antioxidant activity and Anti-Inflammatory Effects of Lemon grass on L-ArginineInduced Acute Pancreatitis in Rats
Abstract: with aqueous extract of lemon grass 400 and 600 mg/Kg/day. While the pancreatitis was induced in the remain groups by L-arginine (2.5 g/kg, 2 i.p. 1hr interval), group 4 served as positive. Groups 5, 6, and 7 were treated with L-arginine + aqueous extract of lemon grass at doses of 400, 600, and 800 mg/Kg/day,p.o, respectively. Group 8 was received L-arginine + L-carnitine (drug) 500 mg/kg/twice a day p.o. Group 9 was given L-arginine + L-carnitine+ aqueous extract of lemon grass 400 mg/Kg/day, p.o. Rats were sacrificed after 15 days and biochemical, hematological, and histopathological examination were assessed. Evaluation of pancreatic superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were carried out. The results revealed that, treatment with lemon grass aqueous extract significantly reduced serum amylase and lipase levels, as well as tumor necrosis factor- ? (TNF-?) and interleukin-1? (IL-1?) cytokines. Administration of lemon grass doses dependently ameliorated alters of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, nitric oxide, and histoarchitectural changes in pancrease tissues. A similar pattern for oxidative stress markers was noticed. Both pancreatic MDA and serum nitric oxide levels were declined by increasing the dosages, on contrary the pancreatic SOD and CAT elevated. Lemon grass markedly decreases the biochemical and histopathologic changes during the early stages of acute pancreatitis, thus preserving the pancreas histologically. This study concluded that using lemon grass as a tea beverage important in acute The present study aimed to evaluate the protective effect of lemon grass aqueous extracts on Larginine-induced acute pancreatitis in rats regarding biomarkers and morphologic changes. This experimental study was performed on Fifty-four male albino rats were divided into nine equal groups. Negative control group received normal saline. Groups 2 and 3 animals were orally administered pancreatitis.
Publication year 2019
Pages 1177-1189
Organization Name
serial title Middle East Journal of Applied Sciences
Author(s) from ARC
Publication Type Journal
↑