Evaluation of the Potential Anti-diabetic Effect of Apium graveolens and Brassica oleracea Extracts in Alloxan induced Diabetic Rats.
Abstract: Celery (Apium graveolens) leaves and broccoli (Brassica oleracea) flowers are used in folk medicine and also they are used in different dishes in Egypt. In the current study, the hypoglycemic and natural antioxidants content of the ethanolic extracts of celery leaves and broccoli flowers were studied. For antioxidant activity, total phenolics (TP), total flavonoids (TF) and vitamin C content were determined; while for hypoglycemic activity diabetes was induced in rats by administration of alloxan (200mg/kg/i.p). Ethanolic extract of celery leaves (CLE) and broccoli flowers (BFE) (150 and 300 mg/kg/b.w for each extract) were administered to diabetic rats for 30 days. Blood glucose (BG), triglycerides (TG), total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, kidney function parameters (urea and creatinine) and liver enzymes (AST and ALT) activities were estimated. Total phenolics (TP) amounts were 30.3 and 38.4 mg/g in CLE and BFE, respectively; total flavonoids (TF) amounts were 18.5 and 22.5 mg/g in CLE and BFE, respectively; while vitamin C was 418.47 and 85.5 mg/kg, respectively. Oral administration of CLE and BFE (150 and 300 mg/kg/b.w) in diabetic rats caused a significant decrease in BG, TG, TC, LDL, urea, creatinine and liver enzymes activities. Our results suggested that CLE and BFE have high content of antioxidants (TP, TF and vitamin C) and also have hypoglycemic effect in diabetic rats.
Keywords: Celery leaves, Broccoli flowers, Hypoglycemic, Antioxidant.
Publication year 2018
Pages 39-44
Organization Name
Author(s) from ARC
External authors (outside ARC)
    مدحت ابو زيد قسم الكيمياء الحيوية، كلية الزراعة، جامعة المنوفية، شبين الكوم، مصر
    محمد سلامة محمد قسم المعامل، مستشفى مشتول السوق، الشرقية، مصر
Publication Type Journal
↑