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Grape Leave Extract Technology and Potential Therapeutic Effects on CCL4 Included liver injury in rat
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Abstract:
This study was undertaken to investigate the putative antioxidant activity of the dried leaves and their water extract clinically in carbon tetrachloride (CCL4) included liver damage in male rats was used. Intraperitoneal administration of CCL4 (2ml/kg) to rats for 4 days resulted in significantly elevated (p<0.05) serum levels of liver enzymes compared to controls. In consequence, significant elevation (p<0.05) of malondialdehyde (MDA) and a lowered level of reduced glutathione (GSH) were observed. When rats with CCL4 induced hepatotoxicity were treated with the dried grape leaves and their water extract, the serum GOT, GPT and ALP levels reverted to near normal. Concurrently, the hepatic concentration of GSH was significantly increased (p<0.05) and that of MDA significantly (p<0.05) lowered when compared to CCL4 exposed untreated rats. Histopathological studies confirmed the hepatoprotective effect profounded by the extracts. The secondary objectives of this study were investigating the potential use of grape leaves the potential use of grape leaves for consumer. Therefore, we cooked rice fortification with grape leaves juice with evaluate the sensory characteristics. The result indicates that fortified grape leaves juice in cooked rice with the percentage 1:2.5 (grape leaves to water, G:W) without adversely affecting physical characteristics or acceptability. These results suggest that grape leaves extract is able to significantly alleviate the hepatoxicity induced by CCL4 and can protect liver against some pathological diseases.
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| Publication year |
2010
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| Organization Name |
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| serial title |
Az. J. Pharm. Sci
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| Author(s) from ARC |
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| Publication Type |
Journal
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