Camel milk protects against CCl4 – induced hepatotoxicity in male albino rats.
Abstract: The camel milk shows a highly promising hepatoprotective effects against CCl4-induced hepatotoxicity in male albino rats. Therefore, the present study aimed to evaluate the protective effects of camel milk against the hepatoprotective and anticirrhosis activities induced in rats by carbon tetrachloride(CCl4). Thirty five, Sprague Dawly healthy, adult male albino rats were utilized in the experimental. The tested rats were classified and labeled in seven groups as follows: G1 (N.C, the normal control group) and G2 (intoxicated control) were fed on basal diet all around the experimental period, All the other treated Groups (G3,G4 and G5) were treated by 2, 3 and 5 ml Camel milk, respectively. G6 was treated by Egyption Mehallabya and G7 treated with Sylimarin (25 mg/kg of body weight).All of groups exept control group, were repeated Intraperitoneal injection.by (CCl4) for 2 weeks serum enzyme activities (AST and ALT) which assisted liver function and Histopathological degenerative changes in heptocytes were also monitored in the treated groups.Camel milk (three doses) and silymarin treatment showed significantly increased levels in enzyme activity when in spite of the repeated administrations with CCl4. However, silymarin converted the liver enzymes activities to the normalized satatus level compared to the control group. silymarin and camel milk decreased enzymes level in the CCl4-elevated tested groups and The Histopathological results revealed that repeated Camel milk treatments with three doses exhibited almost normal architecture, compared to CCl4-treated group. Image analysis of liver revealed, also, a marked reduction in liver damage area after treated rats with the Camel milk and silymarin treatment protocol compared with CCl4-treated group. This indicatin of Camel milk that Camel milk has a protective effect restore structural integrity of hepatocytes cell membrane and regeneration of damaged liver cells. The present study demonstrated that the Camel milk has a hepatoprotective activity in dose dependent manner, whereas the higher dose (5 ml) more effective than the lower dose ( 2 ml). The results showed also that the camel milk have a hepatoprotective against CCl4 induced toixicity on rats. In general, it could be concluded by the camel milk treatments. Drinking camel milk could be beneficial for ameliorating CCL4 toxicity that through estimate the chemical parameters and the histological changes in the rat groups treated but future studies and legislation are required to implement for human poplation and to confirm these protective effects.
Publication year 2012
Organization Name
serial title J. Biol Chem Environ Sci
Author(s) from ARC
External authors (outside ARC)
    سميه صبري معهد بحوث تكنولوجيا الاغذيه
    ملك زهران المركز القومي لبحوث قسم بيولوجيا الخليه
    امام عبد المبدئ -كليه الزراعه –جامعه القاهره –قسم الكيمياء الحيوية
Publication Type Journal
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