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EFFECT OF LOW AND HIGH ESTERIFIED PECTIN ON ARSENIC TOXIFICATION IN RATS
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Abstract: Abstract
The main purpose of the present study is to evaluate the efficiency of each low and high esterified pectin on arsenic absorption, retention and removal in male albino rats (Sprague Dawley strain). Fifty male albino rats were divided into ten groups (5rats for each), the first group was fed on based diet (b d) as a (-)control group (NC), groups (2-4) received b d with 4.0, 8.0 and 16 mg/Kg sodium arsenite (SA) /Kg diet daily as which represents 1/100,1/50 and 1/25 from sodium arsenite, LD50 in the diet as control (+) 1,2 and 3 respectively, groups (5-7) , received bd with 8% high esterified pectin (HEP, DE 73.5) with the previously SA doses and groups (7-10), received bd with 8% low esterified pectin (LEP, DE 31%), and the same SA doses. Rats were fed with LEP with 4.0 mg SA/Kg diet resulted in the best improvement of the nutritional valus in addition to the histopathological changes. At the end of the experiment (30 day) the mean value of serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), uric acid, urea, creatinine and lipid peroxide (TBARS) decreased in the groups were fed HEP or LEP in the presence of the previously SA doses when compared with the same positive control. The best results of the previously parameters obtained in group was fed with 8% LEP with 4.0 mg SA/Kg diet except ALT which obtained with 8.0 mg SA/Kg diet when compared with negative control group
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| Publication year |
2008
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| Organization Name |
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| serial title |
J. Biol. Chem. Environ. Sci
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| Author(s) from ARC |
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| External authors (outside ARC) |
طارق محمد يحي عمر
معمل تحليل العناصر الثقيلة – المركز الاقليمي للأغذية والأعلاف
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| Publication Type |
Journal
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