|
|
BIOLOGICAL EFFECT OF GINGER (ZINGIBER OFFICINALE ROSCOE ) ON DIABETIC PREGNANT AND LACTATING RATS
|
|
Abstract: ABSTRACT
Biochemical and histological effects of ginger as a hypoglycemic agent in diabetic albino pregnant rats were investigated. Water extract of ginger was analyzed for phenolic acid determination by HPLC. Ginger essential oils were also analyzed for its volatile components using GC-MS. A total of 35 pregnant albino rats were divided into 7 groups. Group 1 normal healthy control Group 2 diabetic control which injected with Streptozotocin (STZ) (50mg/kg b.w.) to induce diabetes . Group 3 diabetic rats induced 2g m ginger powder rhizomes/ 100 g diet. Group 4 diabetic rats injected with 3 ml water extract of ginger. Group 5 diabetic rats injected with 0.3 ml essential ginger oil . Group 6 diabitic rats injected with 0.3 ml . Commercial ginger oil . Group 7 diabitic rats injected with 80 mg Dimecron drug . Glucose. Prolactin . lipids profile as well as kidney and liver function were determined in serum . The result showed that ginger water extract had several phenolic compounds. The main of compounds were sakaruntin, lutalin, rutin. Querecetrin and Hyperosaid , these were naturally. GC-MS identified 61 compounds. In the essential oil of ginger . of which the major compounds were Sesquiterpene, geraniol and farnosen. The results also showed that the ginger in forms of powder , rhizomes or oil significantly (p<0.5) Reduced glucose, total lipids. Triglycerides. Total cholesterol. Creatinine, urea and uric acid contents as well as the activity of transaminase ( GPT and GOT ) , alkaline phosphates (ALP ) in blood of diabetic pregnant albino rats. However. An increase in total Protein and albumin/globulin ratio were found compared with the control under the same conditions.
|
| Publication year |
2008
|
| Pages |
93-114
|
| Organization Name |
|
| serial title |
J. Bio. Chem. Environ. Sci
|
| Author(s) from ARC |
|
| External authors (outside ARC) |
|
| Publication Type |
Journal
|