Biochemical evaluation of some oils rich in ?-3 or ?-linolenic acids and their anticancer activity
Abstract: The influence of diets supplemented with evening primrose seeds oil (EPO) or marine alga oil (MO) or linseeds oil (LO) on serum lipid profile, liver and kidney functions in rats were studied. Furthermore the anticancer activity; cytotoxicity of the three on breast, larynx, colon and liver human tumor cell lines tested using sulphorhodamine B (SRB) assay were also studied representing different cancer types. Results revealed that, the serum total cholesterol concentrations of rats fed the EPO or MO or LO diets were significantly lower and the MO diet was the best one in all groups after 6 weeks. Also, HDL-cholesterol levels were significantly increased in all groups; except the 3 week MO group, as compared to the control group.
Moreover, it was observed that EPO after 6 week had the highest value. Triglycerides concentrations in the EPO and LO groups significantly decreased, whereas no significant trend was observed in the MO group. In addition, the supplementations of EPO, MO and LO have no significant effect on liver and kidney functions.
The linseed oil exhibited an efficient cytotoxicity against breast (MCF7), larynx (HEP2) and liver (HEPG2) carcinoma cell line with IC50 values of 4.4, 5.23 and 2.27?g, respectively and did not have cytotoxic effect against colon carcinoma cell line, while MO and EPO did not maintain any cytotoxic property against all tumor cell lines under our experimental conditions.
Publication year 2009
Pages 167-182
Organization Name
serial title مجله الكيمياء والعلوم البيولوجيه
Author(s) from ARC
External authors (outside ARC)
    محجوب محمد احمد الهيئة العامة للرقابة والبحوث الدوائية
Publication Type Journal
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