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Preventive effect of lion's leaves on a level of fats against toxicity with carbon tetrachloride and support for guava and mango pulp
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Abstract: The lion man, widely known as the mantle of the lady, the bear man, or the lion man, is traditionally used for its tannins to treat infections, diarrhea, wound healing, and prevent heart disease, blood vessels, and hepatic fibrosis. This work aims to shed light on the effect of dried lion's leaves and their water and ethanol extracts in different ratios against toxicity of carbon tetrachloride on the content of serum fats that may occur in albino mice. The guava pulp and mango supported with the lion's mill, water and ethanol extracts, have been prepared as a product rich in potent bioactive compounds to help high fat patients. Fifty-six albino mice were used in that experiment. These mice were divided into eight main groups (seven mice in each group) that were fed on the basic meal for 45 days, and then the first group, the negative control group was fed with the basic meal. 49 mice were fed with the basic meal and treated with carbon tetrachloride by subcutaneous injection to induce toxicity and then divided them into seven groups (from group 2 to group 8). The second group: the positive control group that feeds on the main meal until the end of the experiment. Groups from 3 to 8 were treated as the second group with treatment with ethanol extract 50 and 100 ppm, aqueous extract 50 and 100 ppm oral dose daily and with dried leaf powder 1% and 2%, respectively. Guava pulp and mango were also divided into 7 groups as follows: control sample and samples (from 2 to 7) supported by the lion man as an ethanol extract 50 and 100 parts per million and aqueous extract 50 and 100 parts per million and dried leaves powder for sensory evaluation . These samples were evaluated sensitively in terms of general appearance, color, flavor, taste, homogeneity, and general acceptance.
Results: The results showed that the lion's leaves and their ethanol and aqueous extracts caused significant decrease in serum lipid content, total cholesterol, triglycerides, total fats, low density lipoproteins, very low density lipoproteins, and high density lipoproteins in all groups treated with carbon tetrachloride. These results are attributable to the content of the lion's man of antioxidants such as polyphenols, flavonoids, tannins and saponins (359,65, 183,10, 150,46 and 296,32 mg / g dry weight, respectively). The best sample of fortified guava pulp was 1% of dried leaves. Whereas the best result of mango pulp was in the samples supported by 50 ppm ethanol extract, 50 and 100 ppm aqueous extract and 1% of the dried paper.
Conclusion: This study showed that it is suggested to support the lion's leg to protect against toxicity caused by carbon tetrachloride in mice, also to help prevent the development of cardiovascular diseases and cirrhosis.
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| URL |
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| Publication year |
2019
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| Pages |
394-400
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| Organization Name |
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| serial title |
International Journal of Food Science
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| Author(s) from ARC |
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| External authors (outside ARC) |
أمنية جلال رفعت
قسم التغذية و علوم الأطعمة – كلية الإقتصاد المنزلي – جامعة حلوان – القاهرة – مصر
مني سامي حلبي
قسم التغذية و علوم الأطعمة – كلية الإقتصاد المنزلي – جامعة حلوان – القاهرة – مصر
أيه عبد الرحمن عمر
قسم التغذية و علوم الأطعمة – كلية الإقتصاد المنزلي – جامعة حلوان – القاهرة – مصر
إيمان محمد المتولي
قسم الإقتصاد المنزلي- كلية البنات – جامعة عين شمس – القاهرة - مصر
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| Publication Type |
Journal
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