Protective Role of Some Herbal Extracts on Oxidative Stress in Brain and Liver of Streptozotocin-Induced Diabetic Rats
Abstract: Herbal extracts, are popular implementations because of their fragrance and antioxidative activity, which mainly comes from polyphenols. The aim of the study was to investigate the effect of aqueous extracts of green tea, thyme and sage on the occurrence of oxidative stress in the brain and liver of induced diabetes rats by measuring the extent of oxidative damage as well as the status of the antioxidant defense system in such organs. Oral feeding with aqueous extract of the herbal plants supplied to diabetic rats instead of drinking water significantly decreased levels of blood glucose. However, a significantly increment in the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPH-Px) and glutathione reduced (GSH) were observed in brain and liver of diabetic rats treated with all of the extracted solutions at concentrations of 2 and 4%. The treated groups showed a significant decrement in thiobarbituric acid reactive substances (TBARS) in brain and liver. Since the study of induction of the redox enzymes is considered to be a reliable marker for evaluating the antiperoxidative efficacy of the herbal plants, these findings suggest a possible antiperoxidative role derived from such herb extractions. Moreover to the antidiabetic effect and possess antioxidant potential that may be used for therapeutic purposes suggested.
Publication year 2008
Availability location معهد بحوث تكنولوجيا الأغذية
Availability number مركز البحوث الزراعية - ش الجامعه - الجيزة
Organization Name
serial title Egypt.J.Biomed.sci
Author(s) from ARC
Agris Categories Diet and diet-related diseasesHuman nutrition - General aspectsNutrition programmes
AGROVOC
TERMS		 Oxidation. Stress.
Publication Type Journal
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