Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats
Abstract: Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic
system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum
chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3)
Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3-
curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and
15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P? 0.05) increased in liver and kidney
functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same
side, the treatment with AlCl3 alone significantly (P? 0.05) increase the free radical level and decreased the activities of
antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals
and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the
toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in
healthy and AlCl3-treated rats.
Publication year 2019
Pages 64-73
Availability location 2578-9635
Availability number 2578-9643
Organization Name
serial title International Journal of Food Science and Biotechnology
Web Page
Author(s) from ARC
External authors (outside ARC)
    فاطمة الزھراء علي عبدالعال 2 قسم بحوث تصنيع الحاصلات البستانية - معھد بحوث تكنولوجيا الأغذية – مركز البحوث الزراعية – الجيزة – مصر
    سحر زكي 3 قسم التكنولوجيا الحيوية البيئية – معھد بحوث الھندسة الوراثية والتكنولوجيا الحيوية- مدينة الأبحاث العلمية والتطبيقات التكنولوجية- برج العرب، الإسكندرية
Publication Type Journal
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