Effect of Some Antioxidants on Rats Treated with Titanium Dioxide Nanoparticles
Abstract: TITANIUM Dioxide Nanoparticles (TiO2NPs) is used in the production of food colorants,
some nutritional supplements and many other products on large scale. Many studies stated
that the TiO2NPs are more toxic than titanium dioxide (TiO2) and as possibly carcinogenic to
humans. The aim of study was carried out investigate on impacts of vitamin C and vitamin E on
free radicals and antioxidant enzymes activities in male rats treated with TiO2NPs. The obtained
results showed that, there were no significant (P?0.05) differences found in red blood cells
(RBC), hematocrit (Ht), hemoglobin (Hb) and platelets count (PLT) after treated with titanium
dioxide nanoparticles (TiO2NPs) or natural antioxidants (vitamin E and C). The treatment with
TiO2NPs alone caused significant (P?0.05 ) increase in kidney and liver functions, while the
oral intake of V.C and V.E or V.C+V.E reduced this increase. Also, the treatment with TiO2NPs
increased the level of free radicals and decreased the activity of some antioxidant enzymes
such as Superoxide dismutase (SOD),Glutathione-S-transferase (GST) and the content of
Glutathione (GSH) in plasma. Meanwhile, V.C and V.E decreased the increased in free radicals
and protected the activity of antioxidant enzymes in plasma of TiO2NPs- treated rats.
Keywords: Titanium Dioxide Nanoparticles, Natural Antioxidants, Nano- toxicology
Publication year 2019
Pages 91 - 103
Organization Name
serial title Egypt. J. Food. Sci.
Author(s) from ARC
External authors (outside ARC)
    مروة فاروق القاضي قسم الهندسة الكيماوية والبيتروكيماوية - الجامعة المصرية اليابانية - الإسكندرية - مصر
Publication Type Journal
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