Antioxidants activity of Coriander sativum L. and hepatoprotective role against ccl4-induced oxidative stress in rats.
Abstract: The present study was examined to investigate the possible hepatoprotective of the natural antioxidants of Coriander sativum L. seed powder 10% and Coriander essential oil 290mg/kg diet against Ccl4-induced oxidative stress in Sprague-Dawley albino rats. The rats were divided into two main groups. The first (6 rats) fed on the basal diet as a negative control group. The second group (24 rats) treated with Ccl4 in paraffin oil (50% v/v 2 ml/kg) twice a week intraperitoneal injection and divided into four groups (6 rats each) according to the following scheme for 30 days : (1) positive control (received basal diet), group (2) received basal diet with 25mg/kg silymarin, (3) received basal diet with coriander seed powder 10%, (4) received basal diet with coriander essential oil (290mg/kg)diet. Intraperitoneal injection of Ccl4 resulted in significantly increase in the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) with the reduction of antioxidant enzymes. Serum total protein and albumin levels were elevated by coriander essential oil and coriander seed powder against Ccl4-treated rats. Kidney and liver functions were improved by a significant increase in antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Histopathological examination showed that liver injury, large local area of hypatocytes necrosis which completely replaced by massive infiltration with leucocytic of Ccl4-treated rats. Coriander essential oil activity has significant reduction of the toxic effect of Ccl4 when compared to control positive group might be correlated with its antioxidant constituents and free radicals scavenger effects.
Publication year 2009
Pages 381-403
Availability location معهد بحوث تكنولوجيا الأغذية
Availability number
Organization Name
serial title J. Biol. Chem.Environ. Sci
Author(s) from ARC
Agris Categories Feed additivesFood science and technology
AGROVOC
TERMS		 Antioxidants. Coriander. Oxidation. Rats. Stress.
Publication Type Journal
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