AN- IN VITRO EVALUATION FOR SOME NATRUAL SEQUESTRANT RESOURCES
Abstract: Since artificial sequestrants are administrated in chunk amounts and prescribed, in most cases, for long duration of time, an acute adverse effect may frequently be noticed. Taking the drug resin cholestyrmine as a 100% binding bile acid, three groups of natural slowering for enterohepatic circulation exist. The strongest group, i.e. over 30%the drug, has been shown to be black-eye pea, chickpea, dehulled lentil, kidney bean and mung bean. Soybean comes among some other beans as, or little less, the middle group of over than 25 to 30% of the drug. Surprisingly, lupine, enzymatically processed, which was the weakest sequestrant, became one of the strongest when prepared at high PH. Hence, no remarkable changes have been obtained for chickpea and oat in that case, a noticeable drop has been seen for faba and mung beans.The degree of processing of proteolytic enzymes for soy extrudates has confirmed the major role of indigestible protein over the expected role of fiber type or content in manufactured drug from natural sources. In another words, as soy extrudate digests up to a limit of enzymatic action, the potential of indigestible in trapping the bile acid increases. this idea will be the main objective in designing new natural sequestrants. That topic will be investigated in near future . In this research, the more equipotent with less amount of prescribed drug, from naturals of valuable medicinal agent in certain forms, is being observed
Publication year 2004
Pages 43-51
Organization Name
City Cairo
serial title Egypt.J.Agric.Res
Author(s) from ARC
Publication Type Journal
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