LIGHT AND ELECTRON MICROSCOPIC STUDIES ON THE CYTOLOGICAL AND CYTOCHEMICAL EFFECTS OF FOOD ADDITIVES ON THE MAMMALIAN LIVER
Abstract: The effect of monosodium glutamate (MSG) on the liver of albino rats was studied through treating 3 groups of animals with 3 different doses (2, 5, 8 gm/kg body wt.). Each group was studied after 2 and 3 weeks of treatment. MSG induced marked histological, histochemical and ultrastructural changes in the liver tissue, these changes were time and dose dependent. MSG caused a decrease in cytoplasmic granules, nuclear pyknosis, tissue necrosis and fibrosis. It also caused disruption of plasma membranes and swelling of cell organelles such as mitochondria, Golgi apparatus, and endoplasmic reticulum followed by their fragmentation. This was associated with increased number of lysosomes. These changes were reflected on some cytoplasmic inclusions such as polysaccharides, which showed gradual decrease, associated with an increase in the lipid content. Also there was a slight increase in the proteins and nucleic acids followed by considerable decrease. This study indicates that MSG is dangerous at continual high doses and it must be avoided especially in case of patients with hepatic disorders.

Key Words: -
Mammals, rat, liver, MSG, histology, histochemistry, ultrastructure, polysaccharides, lipids, proteins and nucleic acids.
Publication year 2001
Availability location المركز الإقليمي للأغذية والأعلاف - ش جامعه القاهرة - الجيزة
Availability number
Organization Name
Country Egypt
Author(s) from ARC
External authors (outside ARC)
    أ.د عدالرحمن بشطر جامعة القاهرة
    د. فاطمة الزهراء حسين جامعة القاهرة
Proposed Agrovoc السيتولوجية و السيتوكيميائية;
Publication Type Master Thesis
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