Genotype and age affect native immunity traits and oxidative status during suckling period

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Abstract: To investigate the effects of genotype and age on native immunity and oxidative status during suckling period used 40 rabbit does and 40 kits during suckling period from Native Middle-Egypt rabbits (NMER) and from New Zealand White (NZW). A total of 20 blood samples were collected and analyzed at 15 and 30 d of post-partum from rabbits does and kits for each genotype. Native immunity were included Serum Bactericidal Activity – SBA, Hemolytic complement Assay – HCA, lysozyme. Oxidative status (Reactive Oxygen Substances – ROS and total Antioxidant Capacity of plasma, TAC) were estimated in plasma. Genotype and interaction between breed and age were source of significantly variation for lysozyme. Interaction between genotype and age had significantly effect in Serum Bactericidal Activity (SBA) % and Hemolytic complement assay (HCA) CH50. SBA was increased while HCA was decreased at 30 d compared to 15 d in does of local breed (NMER). On the contrary in the does of NZW, the SBA was decreased and HCA was increased at 30 d. In rabbit kits age had a strong significantly influenced in lysozyme and HCA levels. Percentage of SBA was significantly affected by age and the interaction between breed and age. Rabbit kits were characterized by a higher HCA and lower SBA at 15 d compared to at 30 d in both of breeds. Oxidative status measurements in rabbit does inducted to the interaction between genotype and age had significantly effect in Total Antioxidant capacity (TAC) while Reactive Oxygen Substances (ROS) affected by both of breed and age. TAC values in rabbit kits were affected by breed and the interaction between breed and age. Total Antioxidant capacity (TAC) values in rabbit kits were affected by breed and the interaction between breed and age. In the present trial ROS and TAC values in does of NMER were higher than those in NZW at 30 d and this same trend observed in kits of NMER with advanced the age. This may be due to NMER rabbits as a local breed being more rustic, are used to move more and may suffer undergoing injuries when the available space is limited. Both of Lysozyme and SBA presented a significantly positive correlation with Antioxidant capacity. A positive correlation was between Lysozyme and SBA in rabbit kits that may be confirming their immune function as early defense barriers. In conclusion, in rabbit's does of local breed (NMER), blood lysozyme concentration and SBA % increased with advanced of suckling period while complement activity was decreased. An opposite trend was observed for rabbit does of NZW breed. In rabbit kits of both breed (NMER and NZW) increase values observed in serum lysozyme and SBA levels at 30 d compared to 15d post-partum during suckling period that may be indicated an effort to continuously adapt to environmental stress with advanced of age or/and to presence of specific receptors to E. coli on the intestinal epithelium with advanced suckling period in rabbit.
Key words: Native immunity, Oxidative status, Genotype, suckling period, rabbit does, rabbit kits

Publication year

2012

Pages

113-117

Availability location

معهد بحوث الانتاج الحيوانى- شارع نادى الصيد- الدقى- الجيزة

Availability number

Organization Name

Animal Production Research Institute (APRI)

City

شرم الشيخ

serial title