Trials for attenuation of pigeon paramyxoivrus-1 in Mice

Abstract: A preliminiary attempt for possibility of attenuating a local isolate of pigeon paramyxovirus-1 (PPMV-1) was investigated by passaging in weanling mice, aiming for using it as live immunizing agent. After five passages by intracerebral (I/C) route, the virus showed significant reduction of its virulence for SPF chicken embryos and susceptible pigeons as judged by mean death time (MDT), intravenous and intracerebral pathogenicity index (IVPI and ICPI). Disminished pathogenicity was observed without losing its immunogenicity as proved by developing antibody after 21 days. Titre in inoculated pigeons reached 6.8 log2 and 6.5 log2 on the fourth and fifth passages respectively. Such titer level was satisfactory enough to resist inoculation with the virulent strain. Achieved results were highly promising as successful attempt for encouarging further investigation aimed to prepare alive attenuated immunogenic, low cost and effective (PPMV-1) vaccine.
Publication year 2011
Pages 96-105
Organization Name
City الزقازيق
serial title المجلة الطبية البيطرية لكلية الطب البيطري -جامعة الزقازيق
Web Page
ISSN 1110-1458
Author(s) from ARC
External authors (outside ARC)
    ايمان احمد حسن على
    نادية محمد ابراهيم
Agris Categories Pests of animals
AGROVOC
TERMS		 Mice. Paramyxoviridae.
Publication Type Journal
↑