Comparative studies on the immune response elicited in chickens Vaccinated with recombinant avian influenza-fowl pox vaccines As A primary vaccine or prime- boost scheme

Abstract: Comparative immunological studies on different types of live recombinant fowl pox virus containing the avian influenza H5 hemagglutimin (HA) gene (rFP- AI- H5) from several strains were done to evaluate their efficacies susceptible SPF chickens were vaccinated with the rFP-AI-H5/Scotland and rFP-AI- H5/ Irland vaccines as primary or prime-boost vaccination with killed H5N2 vaccine to study the immune response against them through monitoring protection % against local circulating highly pathogenic avian influenza (HPAI) H5N1 strain 28 days post-vaccination. All vaccinated chickens with one or double doses of live recombinant vaccines and challenged with HPAIV succumbed to disease, while those vaccinated with killed vaccine or recombinant vaccines as prime-boosted by killed AI vaccine were protected from severe clinical signs and death. Both rFP- AI-H5/Scotland and rFP-AI-H5/Irland vaccines induced poor protection % when used as one dose (17.7% and 37.5%) or as two doses (23.5% and 47.1%) against HPAIV. In birds vaccinated vaccines (rFP- AI-H5/Scotland and rFP-AI-H5/Irland) became protected after challenge by HP AIV with 87.5, 100, 88.2, 94.1% by using oropharyngeal swabs from the live infected control group as well as the vaccinated chicken, it was observed that the reduction in the viral shedding were 0.3,0.7,0.5,1.3, 2.4,3.9,2.9 and 3.2 corresponding for chicken vaccinated with one and two doses of rFP-AI-H5/Scotland one and two doses of rFP- AI- H5/Irland one and two doses of infactivated H5N2 and r AI-H5 (Scotland and Irland) boosted with inactivated H5N2, respectively. The data clearly indicate that the inactivated AI vaccine confers protection comparable to that of the recombinant as primary vaccine against AIV. While, rFP- AI-H5/Irland was more effective than rFP-AI-H5/Scotland.
Publication year 2011
Pages 171-180
Organization Name
City Zagazig
serial title Zag.Vet.Journal
ISSN 1110-1458
External authors (outside ARC)
    لمياء محمد عمر المعمل المركزي للرقابة على المستحضرات الحيوية البيطرية
    الهام عطا الابياري المعمل المركزي للرقابة على المستحضرات الحيوية البيطرية
    ناصر عباس يوسف شريف المعمل المركزي للرقابة على المستحضرات الحيوية البيطرية
    امل احمد سيد المعمل المركزي للرقابة على المستحضرات الحيوية البيطرية
    اكرام سلامة المعمل المركزي للرقابة على المستحضرات الحيوية البيطرية
Agris Categories Animal diseases
AGROVOC
TERMS		 Avian influenzavirus. Chickens.
Publication Type Journal
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