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The Effect of Rift Valley Fever Vaccines on the Release of Interferon and immunoglubin -M in Vaccinated Cattle.
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Abstract: Rift valley fever (RVF) virus is a mosquito-borne human and animal pathogen associated with large outbreaks of severe disease. This work was to evaluate the release of immunoglobulin – M(IgM) as a humoral immune marker and Y-interferon (y-INF) as a cellular immune marker in calves vaccinated with attenuated MP12RVFV strain and with inactivated ZH501 vaccine using ELISA. In vaccinated calves with attenuated vaccine group, all animals had no specific IgM antibody at day of vaccination and started to increase from day 7 post vaccination with titers 1:200 and 1:400 in five out of eight calves (63%). Also the specific IgM titers reached to the peak at day 14 (1:12800) but decreased to zero on day 56. In inactivated vaccine group the IgM titer raised in three calves (37%) to 1200 or 1400 on day 7 post vaccination and kept constant till day 56. The y-interferon was measured in supernatant of in vitro stimulation of peripheral blood mononuclear cells (PBMCs) after 24, 48 and 72 hours from stimulation with RVFV ; y-INF raised in four calves (50%) in calves vaccinated by attenuated vaccine group while it raised in one calves (12.5%) in inactivated vaccine group II at different time of stimulation. MP12 RVF vaccine produced higher early immune response compared to the inactivated vaccine even with booster dose.
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| Publication year |
2009
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| Pages |
321-329
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| Availability location |
معهد بحوث الامصال و اللقاحات
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| Availability number |
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| Organization Name |
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| City |
Alexandria
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| serial title |
5th scientific conference for Alexandria journal of veterinary science
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| ISSN |
1110-2047
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| Author(s) from ARC |
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| Agris Categories |
Animal diseases
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AGROVOC
TERMS |
Rift valley fever virus.
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| Publication Type |
Conference/Workshop
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