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ECM signalling: orchestrating cell behaviour and misbehaviour
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Abstract: The extracellular matrix (ECM) provides signalling cues that
regulate cell behaviour and orchestrate functions of cells in tissue
formation and homeostasis. The composition of the ECM, its
three-dimensional organization and proteolytic remodelling are
major determinants of the microenvironmental signalling context
that controls cell shape, motility, growth, survival and
differentiation. In recent years, the importance of ECM signalling
has been underscored by the evidence that misregulation of
cell–ECM interactions can contribute to many diseases, including
developmental, immune, haemostasis, degenerative and
malignant disorders. This review discusses recent insights into the
regulatory functions of the ECM and their role in disease, focusing
on cancer as a paradigm.
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| URL |
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| Publication year |
2008
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| Pages |
437-441
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| Availability location |
ADHESION SERIES
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| Availability number |
106
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| Organization Name |
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| External authors (outside ARC) |
Matvey E. Lukashev and Zena Werb
zena@itsa.ucsf.edu
Dept of Anatomy and Program in Cell Biology
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| Publication Type |
Technical Report
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