Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats

Abstract: Iron deficiency anemia (IDA) is a major health concern in developing countries, and
these see an increased incidence in pregnant women and children in particular. The
contribution of dairy products as natural products in drug delivery approaches is inspiring.
This study aimed to analyze the application of iron (Fe) and folic acid (FA) bovine serum
albumin-nanoparticles (BSA-NPs) as anti-anemic pharmacological agents that fortify
stirred functional yogurt (SFY), comparing these with a plain control and SFY fortified
with Fe and FA in free forms. The physicochemical, cytotoxicity,microbiological, viscosity,
oxidative interactions,microstructural, sensorial analyses, and bioavailability properties of
IDA-induced Albino rats were examined. The Transmission Electron Microscope (TEM),
Zetasizer, and Scan Electron Microscope (SEM) were applied. Nanocapsule-fortified
SFY showed an enhanced apparent viscosity, water-holding capacity, microstructure,
least lipid oxidation, and overall sensorial acceptability. Feed that included Fe + FA
nanocapsule-fortified SFY (G6) succeeded in restoring hemoglobin (16.53 gdL?1), iron
(109.25 ?gdL?1), ferritin (33.25 ?gdL?1), and total protein (8.6 gdL?1) at the end of
the 4-week feeding period, with significant competition revealed in calcium and zinc
absorbance. Nanocapsule-fortified SFY showed no adverse effects or architectural
alterations in the liver, kidney, or spleen, as indicated by biochemical and histological
examinations. Bovine serum albumin-nanoparticles (BSA-NPs) of iron (Fe) and folic
acid (FA) can be recommended as anti-anemia supplements in different functional
food applications.
Keywords: anti-anemia, natural products, bioavailability, nano-encapsulated Fe and FA, food supplements, stirred
functional yogurt
Iron deficiency anemia (IDA) is one of the top 20 risk factors for the global distribution of disease
burden. TheWHOis working with the Egyptian government to addressmajor challenges due to the
prevalence of IDA, which is found
Publication year 2021
Organization Name
Author(s) from ARC
External authors (outside ARC)
    أميرة محمد جلال درويش قسم تكنولوجيا الغذاء ، معهد بحوث زراعة الأراضي القاحلة (ALCRI) ، مدينة الأبحاث العلمية والتطبيقات التكنولوجية (SRTA-City) ، برج العرب الجديدة ، الإسكندرية ، مصر
    طارق نور سليمان قسم الألبان ، الصناعات الغذائية وقسم بحوث التغذية ، المركز القومي للبحوث ، القاهرة ، مصر
    حسن الهندي قسم الاقتصاد المنزلي بكلية الزراعة -جامعة الأسكندرية
Publication Type Journal