Studies on some factors affecting immune response against pulpy kidney in sheep
Abstract: The present study was carried out to investigate the effect of simultaneous vaccination with different antigens and the effect of some widely used therapeutic as oxytetracycline, procaine pencillin, streptomycin sulphate, ivermectin, berenil, disodium methyl arsenate, vitamin E, AD3E, vitamin C and selenium on the immune response of animals vaccinated with pulpy kidney vaccine.
Studying the effect of vaccination with different antigens on the immune response of animals vaccianted with pulpy kidney vaccine, showed that the monovalent pulpy kidney vaccine produce immune response more better than the polyvalent clostridial vaccine in both rabbits and sheep. Although the antibody titre was decreased after vaccination with the polyvalent vaccine, it was not significant and it was still high enough to be compared successfully with the standard.
Vaccination of sheep with sheep pox vaccine simultaneously with pulpy kidney vaccine interfere with immune response of pulpy kidney vaccine. Although there was decrease in the antibody titre, it was not significant and the titre was still high enough to protect the animals.
Administration of the commonly used antibiotics (oxytetracycline, procaine pencillin and streptomycin sulphate) at the same time with the 1st and 2nd dose of pulpy kidney vaccine , showed that oxytetracycline and procaine pencillin significantly decrease the antitoxin titre in both rabbits and sheep vaccinated with pulpy kidney vaccine. Although streptomycin sulphate decrease the antitoxin titre in both animals, the difference were not statistically significant.
Ivermectin significantly increase the antitoxin titre in both rabbits and sheep, while berenil and disodium methyl arsenate decrease the antitoxin titre, but the differencese are not significant.
Supplementation of vitamin E significantly increases the antibody production in both rabbits and sheep. Vitamin AD3E injection also increase the antibody titre in sheep but less than the dietary supplemented group, but in rabbits the antibody titre was decreased.
Injection of sodium selenite at the same time with the 1st and 2nd dose of pulpy kidney vaccine slightly decrease the antibody titre in rabbits, but in sheep the immune response is significantly suppressed.
Administrattion of vitamin AD3E injection in combination with sodium selenite in rabbits and sheep showed significant decrease in the antitoxin titre in both animals.
Ascorbic acid supplementaion enhance the immune response in both rabbits and sheep, but the increase in the antitoxin titre is not significant. On the other hand ascorbic acid injection has no prononced influence on the immune response.
Publication year 1993
Availability location معهد بحوث الامصال واللقاحات البيطرية -القاهرة - ش السكة البيضاء - العباسية ص ب 131
Availability number
Organization Name
Country Egypt
Author(s) from ARC
External authors (outside ARC)
    أ.د. ربيع حسن عثمان استاذ بقسم الأمراض المعدية - كلية طب بيطري - جامعة القاهرة
    أ.د. آمال عبد العزيز المولى استاذ بقسم الأمراض المعدية - كلية طب بيطري - جامعة القاهرة
    أ.د. اقبال عبد الحميد فرج وكيل معهد الأمصال واللقاحات البيطرية (سابقا)
Agris Categories Animal diseases
Proposed Agrovoc Pulpy kidney vaccine;Polyvalent clostridial vaccine;
Publication Type PhD Thesis
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