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Effect of dietary protein levels with or without zinc supplementation on : 2. Some blood constituents and immune response efficiency of growing rabbits
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Abstract: A total of 102 New Zealand White (NZW) male rabbits (5 weeks old) were divided into two homogeneous groups. The 1st group was fed on a formulated diet containing 16.34 % CP and the 2nd was fed on diet containing 14.46 % CP (low protein). Each group was divided into three equal sub groups. The 1st sub group was fed on the diet without zinc (Zn) supplementation, the 2nd and the 3rd sub groups were fed on the diet supplemented with 100 mg Zn/kg diet as zinc sulfate (ZnSO4 inorganic form) and zinc methionine (Zn-Met, organic form), respectively. Blood samples were collected from rabbit's at different times to determine some blood constituent and immune response.
Results showed that feeding a low level of protein significantly (P<0.01 or 0.05) decreased serum total protein (TP), albumin (Alb), globulin (Glb), Alb/Glb ratio, creatinine, urea. alkaline phosphatase (AP) and thyroid hormone (T4 & T3) concentrations. while increased insignificantly serum total lipids and cholesterol. Addition Zn increased significantly (P<0.01 or 0.05) serum Zn level, TP, Alb and Alb/Glb ratio, creatinine, aspartate aminotramferase (AST), alanine aminotransferase (ALT), AP, T4 and T3, and significantly (P<0.05) decreased serum total lipids and cholesterol concentrations. Zn-Met supplementation increased significantly (P<0.05) Alb/Glb ratio and insignificantly serum Zn, TP, Alb, AST. ALT and AP levels compared with ZnS04 supplementation.
Rabbits fed diet with low protein had significantly (P< 0.01 or 0.05) lower WBC's count (x103/mm3), lymphocyte percentage, antibody titer against sheep red blood cell (SRBC) at different weeks post immunization and change in ear thickness response at different hours after injection with Phytohemagglutinin (PHA) than those fed diet with 16. 34% CP. Rabbits fed diets with Zn showed significantly (P<0.001 or0.01) higher WBC's count, lymphocyte (%), antibody titer against SRBC and cell mediated immune response at different hours post inoculation of PHA compared with those fed diet without Zn supplementation. Zn-Met increased significantly WBC's count. lymphocyte (%), and antibody titers against SRBC especially at 2nd and 4th weeks post immunization and heighten cellular immunity especially at 9 and 12 hours post injection compared with ZnS04 supplementation. Additions Zn to diet containing 14.46% CP reduced harmful effect resulted from reduction in protein content in the diet and subsequent clearly improved immune response efficiency.
Key words: Rabbit, protein levels, zinc source, blood component, immune efficiency.
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| Publication year |
2006
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| Pages |
277-296
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| Availability location |
معهد بحوث الانتاج الحيوانى- شارع نادى الصيد- الدقى - الجيزة
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| Availability number |
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| Organization Name |
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| serial title |
Egyptian Journal of Rabbit Science
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| Author(s) from ARC |
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| External authors (outside ARC) |
صباح محمود علام
جامعة القاهرة
محمد احمد فؤاد المنيلاوى
جامعة القاهرة
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| Agris Categories |
Animal physiology - Nutrition
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AGROVOC
TERMS |
Blood composition.
Immune response.
Proteins.
Rabbits.
Zinc.
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| Publication Type |
Journal
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