Control Of newcastle disease virus infection in chickens by amantadine.
Abstract: Amantadine, an antiviral compound, was tried to control the severity of Newcastle disease virus in balady chicks. A sum of 150 balady (15 day old) was employed for this study. They were divided into 5 groups. The first group (15 chicks) was kept as a normal control nonifected and nontreated. The second group (15 chicks) was treated with amantadine (10 mg/ chicks) daly for one week in the drinking water. The third group was infected with a velogenic strain of Newcastle disease virus (by i/m injection of 0.5 cc 107 concentration). The 4th group was given amantadine for one week before infection. The 5th group was given the druge in the same dose post infection for one week. Blood samples were collected after one hour and one week post treatment for preparation of serum for estimation of serum ALT, AST, Total proteins, albumin and creatinine. The results revealed that amantadine decreased the mortality rate from 75% in infected chicks to 50% in group given amantadine for one week before infection . Whereas, the drug decreased mortality from 75% to 60% in the group treated with amantadine for one week post infection. Infected nontreated chicks revealed a significantincrease in serum ALT, AST, total proteins and creatinine and a decrease in serum albumin level along the course of the study. Infected chicks treated with amantadine showed a significant decrease in serum ALT, AST, total proteins and creatinine and increase in serum albumin level compared to infected non treated chicks. Non- infected chicks with amantadine showed no significant changes in biochemical parameters.
Publication year 2003
Availability location Animal Health Research Institute (AHRI--Nadi El-Said Street - Dokki - Giza
Availability number
Organization Name
Author(s) from ARC
Agris Categories Animal diseases
AGROVOC
TERMS		 Chickens. Newcastle disease virus.
Proposed Agrovoc Amantadine;
Publication Type Journal
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