The protective effect of Origanum majorana essential oil as antimicrobial and antioxidant
Abstract: Marjoram is extensively used as an aromatic and medicinal plant. Therefore the chemical composition of marjoram essential oil was determined by GC/MS. The thirty eight identified compounds were representing 96.82%. The hydrocarbon compounds accounted 61.48%, while the oxygenated compounds constituted 35.34%. The main compound was α-phyllandrene (8.87%), followed by α-terpinene (7.37%), γ-terpinene (7.25%) and terpinen-4-ol (6.33%). Marjoram essential oil was examined for its antimicrobial activity against 4 bacterial and 7 fungal strains using Disc Diffusion method. Data ascertained that marjoram essential oil had an inhibitory effect against all tested fungal and bacterial strains, especially, at high concentrations, while Saccharomyces cerevisiae NRRLY 2034 was more resistant. Furthermore, antioxidant effect of marjoram essential oil was examined by the 2, 2'-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. Data ascertained that marjoram essential oil exhibited an antioxidant activity, especially, at high concentration (50000 ppm), which gave 88.82% inhibition comparing with the synthetic antioxidant, BHT at 200 ppm which gave 65% inhibition. The biological effect of marjoram essential oil on hypercholesterolemic rats was examined compared with BHT. Results proved that oral administration of marjoram essential oil at 1mg and 2 mg/kg body weight decreased the serum cholesterol, LDL, triglycerides and total lipids compared with control group (rats fed on high fat diet containing cholesterol). Also, feeding with BHT exhibited reduction in the previous parameters. Moreover, marjoram essential oil reduced the liver function enzymes AST and ALT and kidney function (urea, uric acid and creatinine) of rats. On the contrary, oral administration of BHT for 6 weeks increased the liver function enzymes and kidney functions.
URL
Publication year 2009
Pages 285-302
Availability location معهد بحوث تكنولوجيا الاغذية-9ش الجامعة-الجيزة
Availability number
Organization Name
City القاهرة
serial title Faculty of Pharmacy
Web Page
ISSN 1110-6093
Author(s) from ARC
External authors (outside ARC)
    منى محمد عبد المجيد كلية الزراعة
    شاهيناز أحمد حلمى كلية الزراعة
Agris Categories Food processing and preservation
AGROVOC
TERMS		 Antimicrobials. Antioxidants. Essential oils. Origanum.
Publication Type Journal
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